11/18/2023 0 Comments Anti mog syndrome treatmentWe named this phenotype “FLAMCES”, which stands for FLAIR-hyperintense lesions in anti-MOG antibody-associated cerebral cortical encephalitis with seizures. The present study hypothesized that the primary features of this MOG phenotype are the clinical manifestations of cortical encephalitis and seizures, as well as the radio-imaging changes in the cerebral cortical FLAIR hyperintense lesions on MRI. It is difficult to comprehend why Budhram performed investigations in some patients without seizure symptoms, despite naming this rare phenotype FLAMES ( 6). Recently, Budhram systematically reviewed the literature and identified 20 similar cases with clinical symptoms (seizures, headache, fever and cortical symptoms) the MRI scan identified cortical FLAIR-hyperintense lesions in anti-MOG-associated encephalitis with seizures (FLAMES) ( 6). All 4 patients with MOG-IgG positivity described by Ogawa were observed to have experienced seizures and exhibited unilateral hyperintense cortical lesions on magnetic resonance imaging (MRI) fluid attenuated inversion recovery (FLAIR) sequences. Furthermore, encephalitis accompanied by seizures and cortical lesions is a rare anti-MOG phenotype, which was first reported by Ogawa in 2017 ( 5). Recent studies have suggested that MOG-associated demyelinating disease may be an entity distinct from multiple sclerosis (MS), acute disseminated encephalomyelitis (ADEM) and neuromyelitis optica spectrum disorder (NMOSD) ( 1, 3).Įpileptic seizures have been recorded in ~20% of patients with MOG-associated diseases ( 4). The primary clinical phenotypes for MOG-IgG-positive disorders are optic neuritis and myelitis ( 2, 3). Myelin oligodendrocyte glycoprotein (MOG) is a membrane protein expressed on the surface of oligodendrocytes and in myelin sheaths ( 1).
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